MolNFT v1 · #108091 · protein
Structure of the ryanodine receptor at resolution of 6.1 a in closed state
4UWA · Ryanodine receptor 1: “Structure of the ryanodine receptor at resolution of 6.1 a in closed state”. Electron microscopy, 20 pockets (best druggability 0.79). MolNFT v1 #108091 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 4UWA
- Type
- protein
- Length
- 13,296 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ryanodine receptor 1
- UniProt
- P11716
- Pockets
- 20 · best druggability 0.79
Structure
electron microscopy · 1 distinct chain · 63% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Ryanodine receptor 1 | protein | 3324 | 63% helix, 10% strand | P11716 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 954 | 0.79 | 0.81 | 119 | empty |
| 2 | 867 | 0.79 | 0.81 | 108 | empty |
| 3 | 1106 | 0.78 | 0.80 | 140 | empty |
| 4 | 1099 | 0.78 | 0.80 | 112 | empty |
| 5 | 786 | 0.77 | 0.81 | 105 | empty |
Interfaces
4 interfaces between chains.
- A–B · 876 Ų buried · 20 hydrogen bonds · protein-protein
- B–C · 867 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 867 Ų buried · 20 hydrogen bonds · protein-protein
- A–D · 866 Ų buried · 20 hydrogen bonds · protein-protein
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11716
- Elsewhere: RCSB PDB 4UWA · PDBe 4UWA · UniProt P11716
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