MolNFT v1 · #108047 · protein
MCM2-histone complex
4UUZ · Histone H3: “MCM2-histone complex”. X-ray diffraction, 1 pocket (best druggability 0.41). MolNFT v1 #108047 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4UUZ
- Type
- protein
- Length
- 209 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone H3; Histone H4; DNA replication licensing factor MCM2
- EC
- 3.6.4.12
- UniProt
- P02299, P84040, P49736
- Pockets
- 1 · best druggability 0.41
Structure
x-ray diffraction · 3 distinct chains · 57% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone H3 | protein | 78 | 69% helix, 5% strand | P02299 |
| B | Histone H4 | protein | 78 | 64% helix, 5% strand | P84040 |
| C | DNA replication licensing factor MCM2 (EC 3.6.4.12) | protein | 53 | 30% helix, 6% strand | P49736 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 78 | 0.41 | 0.79 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2206 Ų buried · 18 hydrogen bonds · protein-protein
- B–C · 1234 Ų buried · 22 hydrogen bonds · protein-protein
- A–C · 853 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 4UUZ · MCM2-histone complex · the same entry in another collection · chain A against A, TM-score 1.00
- P02299 · AlphaFold monomer V2.0 prediction for histone H3 (P02299) · a predicted model of the same protein · chain A against A, TM-score 0.96
- P84040 · AlphaFold monomer V2.0 prediction for histone H4 (P84040) · a predicted model of the same protein · chain B against A, TM-score 0.92
- P49736 · AlphaFold monomer V2.0 prediction for DNA replication licensing factor MCM2 (P49736) · a predicted model of the same protein · chain C against A, TM-score 0.40
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02299
- Every structure of UniProt P84040
- Every structure of UniProt P49736
- Elsewhere: RCSB PDB 4UUZ · PDBe 4UUZ · UniProt P02299 · UniProt P84040 · UniProt P49736
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.