UniProt P49736
DNA replication licensing factor MCM2 (P49736)
DNA replication licensing factor MCM2 (UniProt P49736), EC 3.6.4.12: 39 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 156 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P49736
- Protein
- DNA replication licensing factor MCM2
- EC
- 3.6.4.12
- Experimental structures
- 39
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 156 · 25 records with a druggable one
Structures
40 records of P49736 in the MolNFT archive: 39 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4UUZ | MCM2-histone complex | x-ray diffraction | C | — | 1 (best 0.41) |
| 4UUZ | MCM2-histone complex | x-ray diffraction | C | — | — |
| 5BNV | Crystal structure of Human MCM2 HBD chaperoning a histone H3-H4 tetramer | x-ray diffraction | F, C | PO4 | 1 (best 0.27) |
| 5BNV | Crystal structure of human MCM2 hbd chaperoning a histone H3-H4 tetramer | x-ray diffraction | F, C | — | — |
| 5BNX | Crystal structure of Human MCM2 HBD and ASF1b chaperoning a histone H3.3-H4 dimer | x-ray diffraction | C | — | 2 (best 0.66) |
| 5BNX | Crystal structure of human MCM2 hbd and ASF1B chaperoning a histone H3.3-H4 dimer | x-ray diffraction | C | — | — |
| 5BO0 | Crystal structure of Human MCM2 HBD and ASF1b chaperoning a histone H3.2-H4 dimer | x-ray diffraction | C | — | 2 (best 0.67) |
| 5BO0 | Crystal structure of human MCM2 hbd and ASF1B chaperoning a histone H3.2-H4 dimer | x-ray diffraction | C | — | — |
| 5C3I | Crystal structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and… | x-ray diffraction | D, H, L, P, T, X | — | 16 (best 0.81) |
| 5C3I | Crystal structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and… | x-ray diffraction | D, H, L, P, T, X | — | — |
| 5JA4 | Crystal structure of human TONSL and MCM2 HBDs binding to a histone H3-H4 tetramer | x-ray diffraction | C | — | — |
| 5JA4 | Crystal structure of human tonsl and MCM2 hbds binding to a histone H3-H4 tetramer | x-ray diffraction | C | — | — |
| 6XTX | CryoEM structure of human CMG bound to ATPgammaS and DNA | electron microscopy | 2 | ZN, ADP | 5 (best 0.85) |
| 6XTX | Cryoem structure of human cmg bound to atpgammas and DNA | electron microscopy | 2 | ZN, ADP | — |
| 6XTY | Cryoem structure of human cmg bound to and-1 (cmga) | electron microscopy | 2 | ZN | — |
| 6YA7 | Cdc7-Dbf4 bound to an Mcm2-S40 derived bivalent substrate | x-ray diffraction | C | ZN, ADP | 3 (best 0.68) |
| 6YA7 | CDC7-DBF4 bound to an MCM2-S40 derived bivalent substrate | x-ray diffraction | C | ZN, ADP | — |
| 7CIZ | Crystal structure of DNAJC9 HBD helix2 in complex with H3.3-H4 dimer and MCM2 HBD | x-ray diffraction | C, G, K | SO4 | 7 (best 0.55) |
| 7CIZ | Crystal structure of DNAJC9 hbd HELIX2 in complex with H3.3-H4 dimer and MCM2 hbd | x-ray diffraction | C, G, K | — | — |
| 7CJ0 | Crystal structure of DNAJC9 HBD in complex with H3.3-H4 dimer and MCM2 HBD | x-ray diffraction | G, H | — | 6 (best 0.58) |
| 7CJ0 | Crystal structure of DNAJC9 hbd in complex with H3.3-H4 dimer and MCM2 hbd | x-ray diffraction | G, H | — | — |
| 7PFO | Core human replisome | electron microscopy | 2 | ZN, MG, ANP | 5 (best 0.85) |
| 7PLO | H. sapiens replisome-CUL2/LRR1 complex | electron microscopy | 2 | ZN, MG, ANP | 5 (best 0.86) |
| 7W1Y | Human MCM double hexamer bound to natural DNA duplex (polyAT/polyTA) | electron microscopy | 2, A | ZN, MG, ATP, ADP | 11 (best 0.89) |
| 7W68 | human single hexameric Mcm2-7 complex | electron microscopy | A | — | 4 (best 0.85) |
| 8B9D | Human replisome bound by Pol Alpha | electron microscopy | 2 | ANP, MG | 5 (best 0.84) |
| 8S09 | H. sapiens MCM2-7 double hexamer bound to double stranded DNA | electron microscopy | 2, A | ATP, MG, ZN, ADP | 9 (best 0.89) |
| 8S0A | H. sapiens MCM2-7 hexamer bound to double stranded DNA | electron microscopy | 2 | ATP, MG, ZN, ADP | 6 (best 0.86) |
| 8S0B | H. sapiens MCM bound to double stranded DNA and ORC6 as part of the MCM-ORC complex | electron microscopy | 2 | AGS, MG, ZN, ADP | 6 (best 0.86) |
| 8S0D | H. sapiens MCM bound to double stranded DNA and ORC1-6 | electron microscopy | 2 | AGS, MG, ZN, ADP | 5 (best 0.87) |
| 8S0E | H. sapiens OCCM bound to double stranded DNA | electron microscopy | 2 | AGS, MG | 6 (best 0.85) |
| 8S0F | H. sapiens OC1M bound to double stranded DNA | electron microscopy | 2 | MG, AGS | 5 (best 0.85) |
| 8W0E | Cryo-EM structure of a human MCM2-7 single hexamer on dsDNA | electron microscopy | 2 | ZN, MG, ATP, ADP | 9 (best 0.88) |
| 8W0F | Cryo-EM structure of a human MCM2-7 double hexamer on dsDNA | electron microscopy | 2, A | ZN, MG, ATP, ADP | 9 (best 0.88) |
| 8W0G | Cryo-EM structure of a human MCM2-7 dimer | electron microscopy | 2, A | ZN, MG, ATP | 6 (best 0.83) |
| 8W0I | Cryo-EM structure of the human MCM2-7 heterohexamer | electron microscopy | 2 | ZN, MG, ATP | 5 (best 0.82) |
| 8YJF | Structure of human SPT16 MD-CTD and MCM2 HBD chaperoning a histone H3-H4 tetramer and an H2A-H2B… | x-ray diffraction | B | — | 4 (best 0.86) |
| 8YJM | Structure of human SPT16 MD-CTD and MCM2 HBD chaperoning a histone H3-H4 tetramer and a single… | x-ray diffraction | B | — | 5 (best 0.71) |
| 9CAQ | Cryo-EM structure of a human MCM2-7 double hexamer formed from independently loaded MCM2-7 single… | electron microscopy | 2, A | ZN, MG, ATP, ADP | 8 (best 0.87) |
| P49736 | AlphaFold monomer V2.0 prediction for DNA replication licensing factor MCM2 (P49736) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 17 records
- MG · Magnesium ion · in 15 records
- ADP · Adenosine-5'-diphosphate · in 12 records
- ATP · Adenosine-5'-triphosphate · in 8 records
- AGS · Phosphothiophosphoric acid-adenylate ester · in 4 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 3 records
- PO4 · Phosphate ion · in 1 record
- SO4 · Sulfate ion · in 1 record
Experiment against prediction
- 8B9D chain 2 against the predicted model P49736: TM-score 0.88, RMSD 3.24 Å
- 6XTY chain 2 against the predicted model P49736: TM-score 0.84, RMSD 3.95 Å
- 7PLO chain 2 against the predicted model P49736: TM-score 0.82, RMSD 3.46 Å
- 8S0E chain 2 against the predicted model P49736: TM-score 0.82, RMSD 4.21 Å
- 8S0F chain 2 against the predicted model P49736: TM-score 0.82, RMSD 4.22 Å
- 6XTX chain 2 against the predicted model P49736: TM-score 0.82, RMSD 4.50 Å
- 6XTX chain 2 against the predicted model P49736: TM-score 0.82, RMSD 4.50 Å
- 7PFO chain 2 against the predicted model P49736: TM-score 0.82, RMSD 3.44 Å
- 7W1Y chain A against the predicted model P49736: TM-score 0.75, RMSD 5.62 Å
- 7W1Y chain 2 against the predicted model P49736: TM-score 0.75, RMSD 5.60 Å
Elsewhere
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