MolNFT v1 · #108043 · protein + DNA
Structure of the DNA binding ets domain of human ETV4 in complex with DNA
4UUV · Ets translocation variant 4: “Structure of the DNA binding ets domain of human ETV4 in complex with DNA”. X-ray diffraction, 11 pockets (best druggability 0.73). MolNFT v1 #108043 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4UUV
- Type
- protein + DNA
- Length
- 911 residues
- Chains
- 24
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ets translocation variant 4; 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3'…
- UniProt
- P43268
- Pockets
- 11 · best druggability 0.73
Structure
x-ray diffraction · 7 distinct chains · 48% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, P | Ets translocation variant 4 | protein | 96 | 48% helix, 13% strand | P43268 |
| B, H, Q, T, W | 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3' | dna | 10 | — | — |
| C, I, L, O, X | 5'-D(*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP)-3' | dna | 9 | — | — |
| D, G, S | Ets translocation variant 4 | protein | 95 | 48% helix, 13% strand | P43268 |
| E, K, N | 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3' | dna | 9 | — | — |
| F, R, U | 5'-D(*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP)-3' | dna | 10 | — | — |
| J, M, V | Ets translocation variant 4 | protein | 94 | 49% helix, 13% strand | P43268 |
Pockets
11 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 55 | 0.73 | 0.98 | 18 | empty |
| 2 | 479 | 0.72 | 0.82 | 40 | empty |
| 3 | 499 | 0.71 | 0.81 | 38 | empty |
| 4 | 567 | 0.66 | 0.77 | 75 | empty |
| 5 | 439 | 0.56 | 0.74 | 36 | empty |
Interfaces
54 interfaces between chains.
- D–G · 866 Ų buried · 1 hydrogen bond · protein-protein
- A–P · 865 Ų buried · 2 hydrogen bonds · protein-protein
- M–S · 862 Ų buried · 2 hydrogen bonds · protein-protein
- J–V · 851 Ų buried · 1 hydrogen bond · protein-protein
- J–L · 563 Ų buried · 14 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 4UUV · Structure of the DNA binding ETS domain of human ETV4 in complex with DNA · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43268
- Elsewhere: RCSB PDB 4UUV · PDBe 4UUV · UniProt P43268
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.