Research workbench
Structure of the DNA binding ets domain of human ETV4 in complex with DNA
Analyse Structure of the DNA binding ets domain of human ETV4 in complex with DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4UUV
- Type
- protein + DNA
- Length
- 911 residues
- Chains
- 24
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ets translocation variant 4; 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3'…
- UniProt
- P43268
- Pockets
- 11 · best druggability 0.73
Structure
x-ray diffraction · 7 distinct chains · 48% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, P | Ets translocation variant 4 | protein | 96 | 48% helix, 13% strand | P43268 |
| B, H, Q, T, W | 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3' | dna | 10 | — | — |
| C, I, L, O, X | 5'-D(*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP)-3' | dna | 9 | — | — |
| D, G, S | Ets translocation variant 4 | protein | 95 | 48% helix, 13% strand | P43268 |
| E, K, N | 5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*GP)-3' | dna | 9 | — | — |
| F, R, U | 5'-D(*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP)-3' | dna | 10 | — | — |
| J, M, V | Ets translocation variant 4 | protein | 94 | 49% helix, 13% strand | P43268 |
Pockets
11 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 55 | 0.73 | 0.98 | 18 | empty |
| 2 | 479 | 0.72 | 0.82 | 40 | empty |
| 3 | 499 | 0.71 | 0.81 | 38 | empty |
| 4 | 567 | 0.66 | 0.77 | 75 | empty |
| 5 | 439 | 0.56 | 0.74 | 36 | empty |
Interfaces
54 interfaces between chains.
- D–G · 866 Ų buried · 1 hydrogen bond · protein-protein
- A–P · 865 Ų buried · 2 hydrogen bonds · protein-protein
- M–S · 862 Ų buried · 2 hydrogen bonds · protein-protein
- J–V · 851 Ų buried · 1 hydrogen bond · protein-protein
- J–L · 563 Ų buried · 14 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 4UUV · Structure of the DNA binding ETS domain of human ETV4 in complex with DNA · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43268
- Elsewhere: RCSB PDB 4UUV · PDBe 4UUV · UniProt P43268
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