MolNFT v1 · #107862 · protein

Crystal structure of entamoeba histolytica lysyl-tRNA synthetase apo form

4UP8 · Lysine--tRNA ligase: “Crystal structure of entamoeba histolytica lysyl-tRNA synthetase apo form”. X-ray diffraction, 6 pockets (best druggability 0.75). MolNFT v1 #107862 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4UP8
Type: protein
Length: 580 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lysine--tRNA ligase
EC: 6.1.1.6
UniProt: C4M7X2
Pockets: 6 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Lysine--tRNA ligase (EC 6.1.1.6)	protein	580	39% helix, 22% strand	C4M7X2

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	859	0.75	0.79	74	empty
2	269	0.64	0.81	39	empty
3	304	0.55	0.76	41	empty
4	357	0.54	0.74	46	empty
5	65	0.34	0.76	14	empty

Compared structures

4UP8 · Crystal structure of Entamoeba histolytica lysyl-tRNA synthetase apo form · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C4M7X2
Elsewhere: RCSB PDB 4UP8 · PDBe 4UP8 · UniProt C4M7X2

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