MolNFT v1 · #107601 · protein

Electron cryo-microscopy structure of PB1-P62 filaments

4UF8 · Sequestosome-1: “Electron cryo-microscopy structure of PB1-P62 filaments”. Electron microscopy, 1 pocket (best druggability 0.41). MolNFT v1 #107601 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4UF8
Type: protein
Length: 400 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sequestosome-1
UniProt: Q13501
Pockets: 1 · best druggability 0.41

Structure

electron microscopy · 1 distinct chain · 22% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, I	Sequestosome-1	protein	100	22% helix, 35% strand	Q13501

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	53	0.41	0.81	16	empty

Interfaces

2 interfaces between chains.

A–I · 124 Å² buried · 2 hydrogen bonds · protein-protein
B–I · 99 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

4UF8 · Electron cryo-microscopy structure of PB1-p62 filaments · the same entry in another collection · chain A against A, TM-score 1.00
Q13501 · AlphaFold monomer V2.0 prediction for sequestosome-1 (Q13501) · a predicted model of the same protein · chain A against A, TM-score 0.83

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13501
Elsewhere: RCSB PDB 4UF8 · PDBe 4UF8 · UniProt Q13501

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