MolNFT v1 · #107514 · protein

X-ray structure and activities of an essential mononegavirales L- protein domain

4UCJ · RNA-directed RNA polymerase L: “X-ray structure and activities of an essential mononegavirales L- protein domain”. X-ray diffraction, 2 ligands (ZN, SO4), 9 pockets (best druggability 0.64). MolNFT v1 #107514 on GenesisL1: 3D…

PDB: 4UCJ
Type: protein
Length: 739 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-directed RNA polymerase L
UniProt: Q6WB93
Ligands: ZN, SO4
Pockets: 9 · best druggability 0.64

Structure

x-ray diffraction · 2 distinct chains · 42% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-directed RNA polymerase L	protein	365	43% helix, 13% strand	Q6WB93
B	RNA-directed RNA polymerase L	protein	374	42% helix, 13% strand	Q6WB93

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B
SO4 · Sulfate ion · ion · 6 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	527	0.64	0.76	50	empty
2	351	0.62	0.78	42	SO4
3	297	0.55	0.76	55	SO4
4	164	0.47	0.76	21	empty
5	70	0.39	0.78	17	empty

Interfaces

1 interface between chains.

A–B · 670 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

4UCJ · X-ray structure and activities of an essential Mo gavirales L- protein domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6WB93
Elsewhere: RCSB PDB 4UCJ · PDBe 4UCJ · UniProt Q6WB93

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