Research workbench
X-ray structure and activities of an essential mononegavirales L- protein domain
Analyse X-ray structure and activities of an essential mononegavirales L- protein domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4UCJ
- Type
- protein
- Length
- 739 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-directed RNA polymerase L
- UniProt
- Q6WB93
- Ligands
- ZN, SO4
- Pockets
- 9 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA-directed RNA polymerase L | protein | 365 | 43% helix, 13% strand | Q6WB93 |
| B | RNA-directed RNA polymerase L | protein | 374 | 42% helix, 13% strand | Q6WB93 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 527 | 0.64 | 0.76 | 50 | empty |
| 2 | 351 | 0.62 | 0.78 | 42 | SO4 |
| 3 | 297 | 0.55 | 0.76 | 55 | SO4 |
| 4 | 164 | 0.47 | 0.76 | 21 | empty |
| 5 | 70 | 0.39 | 0.78 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 670 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 4UCJ · X-ray structure and activities of an essential Mo gavirales L- protein domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6WB93
- Elsewhere: RCSB PDB 4UCJ · PDBe 4UCJ · UniProt Q6WB93
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.