MolNFT v1 · #107437 · protein
Importin alpha 7 delta ibb in complex with influenza PB2 nuclear localization domain
4UAD · Importin subunit alpha-7: “Importin alpha 7 delta ibb in complex with influenza PB2 nuclear localization domain”. X-ray diffraction, 6 pockets (best druggability 0.57). MolNFT v1 #107437 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4UAD
- Type
- protein
- Length
- 500 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-7; Polymerase basic protein 2
- UniProt
- O60684, P31345
- Pockets
- 6 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 65% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit alpha-7 | protein | 425 | 73% helix, 0% strand | O60684 |
| E | Polymerase basic protein 2 | protein | 75 | 17% helix, 25% strand | P31345 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 246 | 0.57 | 0.78 | 34 | empty |
| 2 | 182 | 0.54 | 0.79 | 34 | empty |
| 3 | 91 | 0.47 | 0.81 | 19 | empty |
| 4 | 194 | 0.47 | 0.75 | 32 | empty |
| 5 | 120 | 0.41 | 0.76 | 28 | empty |
Interfaces
1 interface between chains.
- A–E · 1871 Ų buried · 38 hydrogen bonds · protein-protein
Compared structures
- 4UAD · Importin alpha 7 delta IBB in complex with Influenza PB2 Nuclear Localization Domain · the same entry in another collection · chain A against A, TM-score 1.00
- O60684 · AlphaFold monomer V2.0 prediction for importin subunit alpha-7 (O60684) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60684
- Every structure of UniProt P31345
- Elsewhere: RCSB PDB 4UAD · PDBe 4UAD · UniProt O60684 · UniProt P31345
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