MolNFT v1 · #107278 · protein
Importin-alpha minor nls site inhibitor
4U5N · Importin subunit alpha-1: “Importin-alpha minor nls site inhibitor”. X-ray diffraction, 1 ligand (3D4), 1 pocket (best druggability 0.48). MolNFT v1 #107278 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4U5N
- Type
- protein
- Length
- 426 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-1
- UniProt
- P52293
- Ligands
- 3D4
- Pockets
- 1 · best druggability 0.48
Structure
x-ray diffraction · 1 distinct chain · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit alpha-1 | protein | 426 | 73% helix, 0% strand | P52293 |
Ligands and binding sites
- 3D4 · N~2~-[4-(pyridin-3-yl)benzyl]-L-lysyl-N-[(1R,2S,3R)-1-{[(2R)-1-amino-1-oxo-3-phenylpropan-2-yl]amino}-1,3-dihydroxybutan-2-yl]glycinamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 63 | 0.48 | 0.84 | 13 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Elsewhere: RCSB PDB 4U5N · PDBe 4U5N · UniProt P52293
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