MolNFT v1 · #107256 · protein
Crystal structure of the human condensin smc hinge domain heterodimer with short coiled coils
4U4P · Structural maintenance of chromosomes protein 2: “Crystal structure of the human condensin smc hinge domain heterodimer with short coiled coils”. X-ray diffraction, 3 pockets (best druggability 0.79). MolNFT v1 #107256 on GenesisL1…
- PDB
- 4U4P
- Type
- protein
- Length
- 428 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Structural maintenance of chromosomes protein 2; Structural maintenance of chromosomes…
- UniProt
- O95347, Q9NTJ3
- Pockets
- 3 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Structural maintenance of chromosomes protein 2 | protein | 232 | 55% helix, 14% strand | O95347 |
| B | Structural maintenance of chromosomes protein 4 | protein | 196 | 52% helix, 14% strand | Q9NTJ3 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1062 | 0.79 | 0.81 | 85 | empty |
| 2 | 421 | 0.59 | 0.75 | 36 | empty |
| 3 | 59 | 0.31 | 0.76 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 2051 Ų buried · 40 hydrogen bonds · protein-protein
Compared structures
- 4U4P · Crystal structure of the human condensin SMC hinge domain heterodimer with short coiled… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NTJ3 · AlphaFold monomer V2.0 prediction for structural maintenance of chromosomes protein 4… · a predicted model of the same protein · chain B against A, TM-score 0.91
- O95347 · AlphaFold monomer V2.0 prediction for structural maintenance of chromosomes protein 2… · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95347
- Every structure of UniProt Q9NTJ3
- Elsewhere: RCSB PDB 4U4P · PDBe 4U4P · UniProt O95347 · UniProt Q9NTJ3
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