Research workbench
Crystal structure of the human condensin smc hinge domain heterodimer with short coiled coils
Analyse Crystal structure of the human condensin smc hinge domain heterodimer with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4U4P
- Type
- protein
- Length
- 428 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Structural maintenance of chromosomes protein 2; Structural maintenance of chromosomes…
- UniProt
- O95347, Q9NTJ3
- Pockets
- 3 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 54% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Structural maintenance of chromosomes protein 2 | protein | 232 | 55% helix, 14% strand | O95347 |
| B | Structural maintenance of chromosomes protein 4 | protein | 196 | 52% helix, 14% strand | Q9NTJ3 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1062 | 0.79 | 0.81 | 85 | empty |
| 2 | 421 | 0.59 | 0.75 | 36 | empty |
| 3 | 59 | 0.31 | 0.76 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 2051 Ų buried · 40 hydrogen bonds · protein-protein
Compared structures
- 4U4P · Crystal structure of the human condensin SMC hinge domain heterodimer with short coiled… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NTJ3 · AlphaFold monomer V2.0 prediction for structural maintenance of chromosomes protein 4… · a predicted model of the same protein · chain B against A, TM-score 0.91
- O95347 · AlphaFold monomer V2.0 prediction for structural maintenance of chromosomes protein 2… · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95347
- Every structure of UniProt Q9NTJ3
- Elsewhere: RCSB PDB 4U4P · PDBe 4U4P · UniProt O95347 · UniProt Q9NTJ3
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