MolNFT v1 · #10721 · protein
Structural mechanism of enzyme mistargeting in hereditary kidney stone disease in vitro
1J04 · Alanine--glyoxylate aminotransferase: “Structural mechanism of enzyme mistargeting in hereditary kidney stone disease in vitro”. X-ray diffraction, 1 ligand (AOA), 2 pockets (best druggability 0.43). MolNFT v1 #10721 on GenesisL1…
- PDB
- 1J04
- Type
- protein
- Length
- 387 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alanine--glyoxylate aminotransferase
- EC
- 2.6.1.51, 2.6.1.44
- UniProt
- P21549
- Ligands
- AOA
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alanine--glyoxylate aminotransferase (EC 2.6.1.51, 2.6.1.44) | protein | 387 | 41% helix, 13% strand | P21549 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 52 | 0.43 | 0.83 | 13 | empty |
| 2 | 81 | 0.36 | 0.76 | 18 | empty |
Modifications
Observed in the structure: 1 modified (cofactor).
Compared structures
- 1J04 · Structural mechanism of enzyme mistargeting in hereditary kidney stone disease in vitro · the same entry in another collection · chain A against A, TM-score 1.00
- P21549 · AlphaFold monomer V2.0 prediction for serine--pyruvate aminotransferase (P21549) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21549
- Elsewhere: RCSB PDB 1J04 · PDBe 1J04 · UniProt P21549
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