MolNFT v1 · #107166 · protein
Human fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide
4U1P · Tyrosine-protein kinase fyn: “Human fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide”. X-ray diffraction, 1 ligand (NA). MolNFT v1 #107166 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4U1P
- Type
- protein
- Length
- 116 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase fyn; Middle T antigen
- EC
- 2.7.10.2
- UniProt
- P06241, K0F5T5
- Ligands
- NA
Structure
x-ray diffraction · 2 distinct chains · 16% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase fyn (EC 2.7.10.2) | protein | 105 | 17% helix, 31% strand | P06241 |
| B | Middle T antigen | protein | 11 | 0% helix, 9% strand | K0F5T5 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 554 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 4U1P · Human Fyn-SH2 domain in complex with a synthetic high-affinity phospho-peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P06241 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase fyn (P06241) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06241
- Every structure of UniProt K0F5T5
- Elsewhere: RCSB PDB 4U1P · PDBe 4U1P · UniProt P06241 · UniProt K0F5T5
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