MolNFT v1 · #107155 · protein
Crystal structure of the EIF3B-CTD/EIF3I/EIF3G-ntd translation initiation complex
4U1E · Eukaryotic translation initiation factor 3 subunit I: “Crystal structure of the EIF3B-CTD/EIF3I/EIF3G-ntd translation initiation complex”. X-ray diffraction, 5 pockets (best druggability 0.81). MolNFT v1 #107155 on GenesisL1: 3D…
- PDB
- 4U1E
- Type
- protein
- Length
- 466 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 3 subunit I; Eukaryotic translation initiation…
- UniProt
- A6ZMK5, P06103, Q04067
- Pockets
- 5 · best druggability 0.81
Structure
x-ray diffraction · 3 distinct chains · 16% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| I | Eukaryotic translation initiation factor 3 subunit I | protein | 330 | 6% helix, 52% strand | A6ZMK5 |
| B | Eukaryotic translation initiation factor 3 subunit B | protein | 47 | 79% helix, 0% strand | P06103 |
| G | Eukaryotic translation initiation factor 3 subunit G | protein | 89 | 21% helix, 26% strand | Q04067 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 421 | 0.81 | 0.89 | 38 | empty |
| 2 | 222 | 0.57 | 0.79 | 25 | empty |
| 3 | 150 | 0.43 | 0.75 | 24 | empty |
| 4 | 92 | 0.36 | 0.75 | 18 | empty |
| 5 | 59 | 0.34 | 0.77 | 14 | empty |
Interfaces
3 interfaces between chains.
- I–G · 1655 Ų buried · 31 hydrogen bonds · protein-protein
- I–B · 1082 Ų buried · 8 hydrogen bonds · protein-protein
- B–G · 69 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4U1E · Crystal structure of the eIF3b-CTD/eIF3i/eIF3g-NTD translation initiation complex · the same entry in another collection · chain I against I, TM-score 1.00
- A6ZMK5 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit… · a predicted model of the same protein · chain I against A, TM-score 0.99
- P06103 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit… · a predicted model of the same protein · chain B against A, TM-score 0.78
- Q04067 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit… · a predicted model of the same protein · chain G against A, TM-score 0.61
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A6ZMK5
- Every structure of UniProt P06103
- Every structure of UniProt Q04067
- Elsewhere: RCSB PDB 4U1E · PDBe 4U1E · UniProt A6ZMK5 · UniProt P06103 · UniProt Q04067
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