MolNFT v1 · #107116 · protein

Hexameric HIV-1 ca in complex with CPSF6 peptide, P6 crystal form

4U0A · Capsid protein P24: “Hexameric HIV-1 ca in complex with CPSF6 peptide, P6 crystal form”. X-ray diffraction, 1 ligand (CL). MolNFT v1 #107116 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4U0A
Type: protein
Length: 222 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Capsid protein P24; Cleavage and polyadenylation specificity factor subunit 6
UniProt: P12493, Q16630
Ligands: CL

Structure

x-ray diffraction · 2 distinct chains · 57% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Capsid protein P24	protein	208	61% helix, 3% strand	P12493
B	Cleavage and polyadenylation specificity factor subunit 6	protein	14	0% helix, 0% strand	Q16630

Ligands and binding sites

CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 552 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

4U0A · Hexameric HIV-1 CA in complex with CPSF6 peptide, P6 crystal form · the same entry in another collection · chain A against A, TM-score 1.00
Q16630 · AlphaFold monomer V2.0 prediction for cleavage and polyadenylation specificity factor… · a predicted model of the same protein · chain B against A, TM-score 0.35

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P12493
Every structure of UniProt Q16630
Elsewhere: RCSB PDB 4U0A · PDBe 4U0A · UniProt P12493 · UniProt Q16630

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