UniProt Q16630
Cleavage and polyadenylation specificity factor subunit 6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (UniProt Q16630): 22 experimental structures and 1 predicted model on GenesisL1, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q16630
- Protein
- Cleavage and polyadenylation specificity factor subunit 6
- Experimental structures
- 22
- Predicted models
- 1
- Pockets
- 3 · 1 record with a druggable one
Structures
23 records of Q16630 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3P5T | CFIm25-CFIm68 complex | x-ray diffraction | L, M, N, O, P, Q | — | — |
| 3P5T | CFIM25-CFIM68 complex | x-ray diffraction | L, M, N, O, P, Q | — | — |
| 3P6Y | CF Im25-CF Im68-UGUAA complex | x-ray diffraction | C, D, G, H, K, L, O, P | — | — |
| 3P6Y | Cf IM25-cf IM68-uguaa complex | x-ray diffraction | C, D, G, H, K, L, O, P | — | — |
| 3Q2S | Crystal Structure of CFIm68 RRM/CFIm25 complex | x-ray diffraction | C, D | — | — |
| 3Q2S | Crystal structure of CFIM68 RRM/CFIM25 complex | x-ray diffraction | C, D | — | — |
| 3Q2T | Crystal Structure of CFIm68 RRM/CFIm25/RNA complex | x-ray diffraction | C, D | — | — |
| 3Q2T | Crystal structure of CFIM68 RRM/CFIM25/RNA complex | x-ray diffraction | C, D | — | — |
| 4B4N | CPSF6 defines a conserved capsid interface that modulates HIV-1 replication | x-ray diffraction | B | — | — |
| 4B4N | CPSF6 defines a conserved capsid interface that modulates HIV-1 replication | x-ray diffraction | B | — | — |
| 4U0A | Hexameric HIV-1 CA in complex with CPSF6 peptide, P6 crystal form | x-ray diffraction | B | — | — |
| 4U0A | Hexameric HIV-1 ca in complex with CPSF6 peptide, P6 crystal form | x-ray diffraction | B | — | — |
| 4U0B | Hexamer HIV-1 CA in complex with CPSF6 peptide, P212121 crystal form | x-ray diffraction | M, N, O, P, Q, R, S, T, U, V, W, X | — | — |
| 4U0B | Hexamer HIV-1 ca in complex with CPSF6 peptide, P212121 crystal form | x-ray diffraction | M, N, O, P, Q, R, S, T, U, V, W, X | — | — |
| 4WYM | Structural basis of HIV-1 capsid recognition by CPSF6 | x-ray diffraction | M, N, O, P, Q, R, S, T, U, V, W | — | — |
| 6AY9 | Structure of the native full-length HIV-1 capsid protein in complex with CPSF6 peptide | x-ray diffraction | B | — | — |
| 6AY9 | Structure of the native full-length HIV-1 capsid protein in complex with CPSF6 peptide | x-ray diffraction | B | — | — |
| 6GX9 | Crystal structure of the TNPO3 - CPSF6 RSLD complex | x-ray diffraction | C, D | — | — |
| 6GX9 | Crystal structure of the TNPO3 - CPSF6 rsld complex | x-ray diffraction | C, D | — | — |
| 7ZUD | Crystal structure of HIV-1 capsid IP6-CPSF6 complex | x-ray diffraction | M | — | — |
| 7ZUD | Crystal structure of HIV-1 capsid IP6-CPSF6 complex | x-ray diffraction | M | — | — |
| 8EJL | Structure of HIV-1 capsid declination in complex with CPSF6-FG peptide | electron microscopy | Y, Z | — | 3 (best 0.60) |
| Q16630 | AlphaFold monomer V2.0 prediction for cleavage and polyadenylation specificity factor subunit 6… | predicted | A | — | — |
Experiment against prediction
- 3P5T chain P against the predicted model Q16630: TM-score 0.99, RMSD 0.37 Å
- 3P5T chain P against the predicted model Q16630: TM-score 0.99, RMSD 0.37 Å
- 3P6Y chain L against the predicted model Q16630: TM-score 0.99, RMSD 0.38 Å
- 3P6Y chain L against the predicted model Q16630: TM-score 0.99, RMSD 0.38 Å
- 3P6Y chain G against the predicted model Q16630: TM-score 0.99, RMSD 0.41 Å
- 3P6Y chain G against the predicted model Q16630: TM-score 0.99, RMSD 0.41 Å
- 3P5T chain N against the predicted model Q16630: TM-score 0.98, RMSD 0.42 Å
- 3P5T chain N against the predicted model Q16630: TM-score 0.98, RMSD 0.42 Å
- 3P5T chain O against the predicted model Q16630: TM-score 0.98, RMSD 0.54 Å
- 3P5T chain O against the predicted model Q16630: TM-score 0.98, RMSD 0.54 Å
Elsewhere
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