MolNFT v1 · #107052 · protein

Structural analysis of the human fibroblast growth factor receptor 4 kinase

4TYG: “Structural analysis of the human fibroblast growth factor receptor 4 kinase”. X-ray diffraction, 2 pockets (best druggability 0.75). MolNFT v1 #107052 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4TYG
Type: protein
Length: 293 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fibroblast growth factor receptor 4
EC: 2.7.10.1
UniProt: P22455
Pockets: 2 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fibroblast growth factor receptor 4 (EC 2.7.10.1)	protein	293	37% helix, 15% strand	P22455

Ligands and binding sites

ACT · Acetate ion · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	614	0.75	0.82	67	empty
2	53	0.26	0.73	17	empty

Compared structures

4TYG · Structural analysis of the human Fibroblast Growth Factor Receptor 4 Kinase · the same entry in another collection · chain A against A, TM-score 1.00
P22455 · AlphaFold monomer V2.0 prediction for fibroblast growth factor receptor 4 (P22455) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22455
Elsewhere: RCSB PDB 4TYG · PDBe 4TYG · UniProt P22455

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