MolNFT v1 · #107018 · protein

Crystal structure of hisap from streptomyces sviceus with degraded profar

4TX9 · Phosphoribosyl isomerase a: “Crystal structure of hisap from streptomyces sviceus with degraded profar”. X-ray diffraction, 2 ligands (AMZ, SO4), 2 pockets (best druggability 0.83). MolNFT v1 #107018 on GenesisL1: 3D structure…

PDB: 4TX9
Type: protein
Length: 246 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phosphoribosyl isomerase a
UniProt: B5I4P8
Ligands: AMZ, SO4
Pockets: 2 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Phosphoribosyl isomerase a	protein	246	40% helix, 25% strand	B5I4P8

Ligands and binding sites

AMZ · Aminoimidazole 4-carboxamide ribonucleotide · ligand · chains A
SO4 · Sulfate ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	239	0.83	0.95	44	SO4, AMZ
2	112	0.48	0.80	16	empty

Modifications

Observed in the structure: 2 modified (engineered).

Compared structures

4TX9 · Crystal structure of HisAp from Streptomyces sviceus with degraded ProFAR · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B5I4P8
Elsewhere: RCSB PDB 4TX9 · PDBe 4TX9 · UniProt B5I4P8

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