MolNFT v1 · #106881 · protein
Crystal structure of ATAD2A bromodomain complexed with H4(1-20)K5AC peptide
4TT2 · ATPase family aaa domain-containing protein 2: “Crystal structure of ATAD2A bromodomain complexed with H4(1-20)K5AC peptide”. X-ray diffraction, 1 pocket (best druggability 0.33). MolNFT v1 #106881 on GenesisL1: 3D structure…
- PDB
- 4TT2
- Type
- protein
- Length
- 136 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATPase family aaa domain-containing protein 2; Histone H4K5AC
- EC
- 3.6.1.3
- UniProt
- Q6PL18
- Pockets
- 1 · best druggability 0.33
Structure
x-ray diffraction · 2 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATPase family aaa domain-containing protein 2 (EC 3.6.1.3) | protein | 130 | 74% helix, 0% strand | Q6PL18 |
| P | Histone H4K5AC | protein | 6 | 0% helix, 0% strand | — |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 71 | 0.33 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–P · 449 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (acetylation).
Compared structures
- 4TT2 · Crystal structure of ATAD2A bromodomain complexed with H4(1-20)K5Ac peptide · the same entry in another collection · chain A against A, TM-score 1.00
- Q6PL18 · AlphaFold monomer V2.0 prediction for ATPase family aaa domain- containing protein 2… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6PL18
- Elsewhere: RCSB PDB 4TT2 · PDBe 4TT2 · UniProt Q6PL18
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