MolNFT v1 · #106863 · protein
Crystal structure of the mib repeat domain of mind bomb 1
4TSE · E3 ubiquitin-protein ligase MIB1: “Crystal structure of the mib repeat domain of mind bomb 1”. X-ray diffraction, 2 pockets (best druggability 0.56). MolNFT v1 #106863 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4TSE
- Type
- protein
- Length
- 313 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 ubiquitin-protein ligase MIB1
- EC
- 6.3.2.-
- UniProt
- Q86YT6
- Pockets
- 2 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 23% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase MIB1 (EC 6.3.2.-) | protein | 157 | 23% helix, 29% strand | Q86YT6 |
| B | E3 ubiquitin-protein ligase MIB1 (EC 6.3.2.-) | protein | 156 | 22% helix, 29% strand | Q86YT6 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 304 | 0.56 | 0.76 | 53 | empty |
| 2 | 241 | 0.52 | 0.76 | 32 | empty |
Interfaces
1 interface between chains.
- A–B · 1106 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 4TSE · Crystal Structure of the Mib Repeat Domain of Mind bomb 1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q86YT6 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase MIB1 (Q86YT6) · a predicted model of the same protein · chain B against A, TM-score 0.47
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86YT6
- Elsewhere: RCSB PDB 4TSE · PDBe 4TSE · UniProt Q86YT6
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