MolNFT v1 · #106784 · protein

Crystal structure of human ATG5-tecair

4TQ1 · Autophagy protein 5: “Crystal structure of human ATG5-tecair”. X-ray diffraction, 1 pocket (best druggability 0.30). MolNFT v1 #106784 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4TQ1
Type: protein
Length: 290 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Autophagy protein 5; Tectonin beta-propeller repeat-containing protein 1
UniProt: Q9H1Y0, Q7Z6L1
Pockets: 1 · best druggability 0.30

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Autophagy protein 5	protein	258	37% helix, 19% strand	Q9H1Y0
B	Tectonin beta-propeller repeat-containing protein 1	protein	32	56% helix, 6% strand	Q7Z6L1

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	57	0.30	0.75	17	empty

Interfaces

1 interface between chains.

A–B · 1303 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

4TQ1 · Crystal structure of human ATG5-TECAIR · the same entry in another collection · chain A against A, TM-score 1.00
Q9H1Y0 · AlphaFold monomer V2.0 prediction for autophagy protein 5 (Q9H1Y0) · a predicted model of the same protein · chain A against A, TM-score 0.96
Q7Z6L1 · AlphaFold monomer V2.0 prediction for tectonin beta-propeller repeat- containing protein… · a predicted model of the same protein · chain B against A, TM-score 0.57

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H1Y0
Every structure of UniProt Q7Z6L1
Elsewhere: RCSB PDB 4TQ1 · PDBe 4TQ1 · UniProt Q9H1Y0 · UniProt Q7Z6L1

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