MolNFT v1 · #106706 · protein
Structure of the bbox-coiled-coil region of rhesus TRIM5ALPHA
4TN3 · TRIM5/CYCLOPHILIN a fusion PROTEIN/T4 lysozyme chimera: “Structure of the bbox-coiled-coil region of rhesus TRIM5ALPHA”. X-ray diffraction, 1 ligand (ZN), 5 pockets (best druggability 0.65). MolNFT v1 #106706 on GenesisL1: 3D…
- PDB
- 4TN3
- Type
- protein
- Length
- 721 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRIM5/CYCLOPHILIN a fusion PROTEIN/T4 lysozyme chimera
- EC
- 3.2.1.17
- UniProt
- G9MAP5, P00720
- Ligands
- ZN
- Pockets
- 5 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 63% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TRIM5/CYCLOPHILIN a fusion PROTEIN/T4 lysozyme chimera (EC 3.2.1.17) | protein | 359 | 65% helix, 6% strand | G9MAP5, P00720 |
| B | TRIM5/CYCLOPHILIN a fusion PROTEIN/T4 lysozyme chimera (EC 3.2.1.17) | protein | 362 | 61% helix, 6% strand | G9MAP5, P00720 |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 446 | 0.65 | 0.78 | 33 | empty |
| 2 | 474 | 0.61 | 0.75 | 55 | empty |
| 3 | 187 | 0.50 | 0.77 | 35 | empty |
| 4 | 186 | 0.46 | 0.75 | 28 | empty |
| 5 | 84 | 0.39 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 5134 Ų buried · 41 hydrogen bonds · protein-protein
Compared structures
- 4TN3 · Structure of the BBox-Coiled-coil region of Rhesus Trim5alpha · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G9MAP5
- Every structure of UniProt P00720
- Elsewhere: RCSB PDB 4TN3 · PDBe 4TN3 · UniProt G9MAP5 · UniProt P00720
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