MolNFT v1 · #106635 · protein

Native-sad phasing for human EGFR kinase domain.

4TKS · Epidermal growth factor receptor: “Native-sad phasing for human EGFR kinase domain.”. X-ray diffraction, 2 pockets (best druggability 0.62). MolNFT v1 #106635 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4TKS
Type: protein
Length: 307 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Epidermal growth factor receptor
EC: 2.7.10.1
UniProt: P00533
Pockets: 2 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Epidermal growth factor receptor (EC 2.7.10.1)	protein	307	34% helix, 19% strand	P00533

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	327	0.62	0.79	32	empty
2	82	0.44	0.80	17	empty

Compared structures

4TKS · Native-SAD phasing for human EGFR kinase domain. · the same entry in another collection · chain A against A, TM-score 1.00
P00533 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor (P00533) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00533
Elsewhere: RCSB PDB 4TKS · PDBe 4TKS · UniProt P00533

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