MolNFT v1 · #106403 · protein

Crystal structure of human fanconi-associated nuclease 1

4RY3: “Crystal structure of human fanconi-associated nuclease 1”. X-ray diffraction, 1 ligand (PT), 8 pockets (best druggability 0.61). MolNFT v1 #106403 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4RY3
Type: protein
Length: 593 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fanconi-associated nuclease 1
EC: 3.1.21.-, 3.1.4.1
UniProt: Q9Y2M0
Ligands: PT
Pockets: 8 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 58% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fanconi-associated nuclease 1 (EC 3.1.21.-, 3.1.4.1)	protein	593	58% helix, 7% strand	Q9Y2M0

Ligands and binding sites

PT · Platinum (II) ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	386	0.61	0.77	35	empty
2	57	0.60	0.92	20	empty
3	297	0.57	0.77	33	empty
4	166	0.44	0.75	28	empty
5	126	0.43	0.76	25	empty

Compared structures

4RY3 · Crystal structure of human Fanconi-associated nuclease 1 · the same entry in another collection · chain A against A, TM-score 1.00
Q9Y2M0 · AlphaFold monomer V2.0 prediction for fanconi-associated nuclease 1 (Q9Y2M0) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9Y2M0
Elsewhere: RCSB PDB 4RY3 · PDBe 4RY3 · UniProt Q9Y2M0

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