MolNFT v1 · #106198 · protein
Crystal structure of receptor-cytokine complex
4RS1 · Granulocyte-macrophage colony-stimulating factor receptor…: “Crystal structure of receptor-cytokine complex”. X-ray diffraction, 1 ligand (NAG), 5 pockets (best druggability 0.66). MolNFT v1 #106198 on GenesisL1: 3D structure…
- PDB
- 4RS1
- Type
- protein
- Length
- 372 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Granulocyte-macrophage colony-stimulating factor receptor subunit alpha…
- UniProt
- P15509, P04141
- Ligands
- NAG
- Pockets
- 5 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 16% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha | protein | 267 | 3% helix, 45% strand | P15509 |
| A | Granulocyte-macrophage colony-stimulating factor | protein | 105 | 50% helix, 8% strand | P04141 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains B
- GOL · Glycerol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 298 | 0.66 | 0.82 | 28 | empty |
| 2 | 135 | 0.64 | 0.87 | 25 | empty |
| 3 | 177 | 0.61 | 0.83 | 17 | empty |
| 4 | 70 | 0.37 | 0.78 | 18 | empty |
| 5 | 72 | 0.32 | 0.74 | 13 | empty |
Interfaces
1 interface between chains.
- B–A · 1249 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 4RS1 · Crystal structure of receptor-cytokine complex · the same entry in another collection · chain B against B, TM-score 1.00
- P15509 · AlphaFold monomer V2.0 prediction for granulocyte-macrophage colony- stimulating factor… · a predicted model of the same protein · chain B against A, TM-score 0.98
- P04141 · AlphaFold monomer V2.0 prediction for granulocyte-macrophage colony- stimulating factor… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15509
- Every structure of UniProt P04141
- Elsewhere: RCSB PDB 4RS1 · PDBe 4RS1 · UniProt P15509 · UniProt P04141
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