UniProt P04141
Granulocyte-macrophage colony-stimulating factor (P04141)
Granulocyte-macrophage colony-stimulating factor (UniProt P04141): 15 experimental structures and 1 predicted model on GenesisL1, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P04141
- Protein
- Granulocyte-macrophage colony-stimulating factor
- Experimental structures
- 15
- Predicted models
- 1
- Pockets
- 7 · 1 record with a druggable one
Structures
16 records of P04141 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CSG | Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor | x-ray diffraction | A, B | — | — |
| 1CSG | Three-dimensional structure of recombinant human granulocyte- macrophage colony-stimulating factor | x-ray diffraction | A, B | — | — |
| 2GMF | Human granulocyte macrophage colony stimulating factor | x-ray diffraction | A, B | — | — |
| 2GMF | Human granulocyte macrophage colony stimulating factor | x-ray diffraction | A, B | — | — |
| 4NKQ | Structure of a Cytokine Receptor Complex | x-ray diffraction | C | — | — |
| 4NKQ | Structure of a cytokine receptor complex | x-ray diffraction | C | — | — |
| 4RS1 | Crystal structure of receptor-cytokine complex | x-ray diffraction | A | — | — |
| 4RS1 | Crystal structure of receptor-cytokine complex | x-ray diffraction | A | — | — |
| 5C7X | Crystal structure of MOR04357, a neutralizing anti-human GM-CSF antibody Fab fragment in complex… | x-ray diffraction | A, B | — | 7 (best 0.72) |
| 5C7X | Crystal structure of MOR04357, a neutralizing anti-human gm-csf antibody Fab fragment in complex… | x-ray diffraction | A, B | — | — |
| 5D70 | Crystal structure of MOR03929, a neutralizing anti-human gm-csf antibody Fab fragment in complex… | x-ray diffraction | A | — | — |
| 5D71 | Crystal structure of MOR04302, a neutralizing anti-human gm-csf antibody Fab fragment in complex… | x-ray diffraction | A | — | — |
| 5D72 | Crystal structure of MOR04252, a neutralizing anti-human gm-csf antibody Fab fragment in complex… | x-ray diffraction | A, B | — | — |
| 6BFQ | The mechanism of gm-csf inhibition by human gm-csf auto-antibodies | x-ray diffraction | G, J, I, K | — | — |
| 6BFS | The mechanism of gm-csf inhibition by human gm-csf auto-antibodies | x-ray diffraction | C | — | — |
| P04141 | AlphaFold monomer V2.0 prediction for granulocyte-macrophage colony- stimulating factor (P04141) | predicted | A | — | — |
Experiment against prediction
- 5D72 chain A against the predicted model P04141: TM-score 0.98, RMSD 0.67 Å
- 4RS1 chain A against the predicted model P04141: TM-score 0.97, RMSD 0.64 Å
- 4RS1 chain A against the predicted model P04141: TM-score 0.97, RMSD 0.64 Å
- 5C7X chain A against the predicted model P04141: TM-score 0.97, RMSD 0.76 Å
- 5C7X chain A against the predicted model P04141: TM-score 0.97, RMSD 0.76 Å
- 6BFQ chain J against the predicted model P04141: TM-score 0.97, RMSD 0.67 Å
- 6BFQ chain K against the predicted model P04141: TM-score 0.96, RMSD 0.78 Å
- 6BFQ chain I against the predicted model P04141: TM-score 0.96, RMSD 0.72 Å
- 6BFS chain C against the predicted model P04141: TM-score 0.96, RMSD 0.94 Å
- 5D71 chain A against the predicted model P04141: TM-score 0.96, RMSD 0.88 Å
Elsewhere
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