MolNFT v1 · #105833 · protein
Crystal structure of a TAF1-TAF7 complex in human transcription factor iid
4RGW · Transcription initiation factor tfiid subunit 1: “Crystal structure of a TAF1-TAF7 complex in human transcription factor iid”. X-ray diffraction, 9 pockets (best druggability 0.69). MolNFT v1 #105833 on GenesisL1: 3D structure…
- PDB
- 4RGW
- Type
- protein
- Length
- 529 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription initiation factor tfiid subunit 1; Transcription initiation factor tfiid…
- EC
- 2.3.1.48, 2.7.11.1
- UniProt
- P21675, Q15545
- Pockets
- 9 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription initiation factor tfiid subunit 1 (EC 2.3.1.48, 2.7.11.1) | protein | 406 | 34% helix, 19% strand | P21675 |
| B | Transcription initiation factor tfiid subunit 7 | protein | 123 | 20% helix, 42% strand | Q15545 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 340 | 0.69 | 0.82 | 42 | empty |
| 2 | 458 | 0.68 | 0.79 | 44 | empty |
| 3 | 101 | 0.52 | 0.83 | 21 | empty |
| 4 | 136 | 0.51 | 0.79 | 23 | empty |
| 5 | 103 | 0.42 | 0.77 | 18 | GOL |
Interfaces
1 interface between chains.
- A–B · 4059 Ų buried · 79 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 4RGW · Crystal Structure of a TAF1-TAF7 Complex in Human Transcription Factor IID · the same entry in another collection · chain A against A, TM-score 1.00
- P21675 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 1… · a predicted model of the same protein · chain A against A, TM-score 1.00
- Q15545 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 7… · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21675
- Every structure of UniProt Q15545
- Elsewhere: RCSB PDB 4RGW · PDBe 4RGW · UniProt P21675 · UniProt Q15545
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