MolNFT v1 · #105777 · protein

Crystal structure of double-domain arginine kinase from anthopleura japonicas

4RF6: “Crystal structure of double-domain arginine kinase from anthopleura japonicas”. X-ray diffraction, 9 pockets (best druggability 0.78). MolNFT v1 #105777 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4RF6
Type: protein
Length: 1,394 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Arginine kinase
EC: 2.7.3.3
UniProt: O15992
Pockets: 9 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Arginine kinase (EC 2.7.3.3)	protein	696	41% helix, 17% strand	O15992
B	Arginine kinase (EC 2.7.3.3)	protein	698	40% helix, 17% strand	O15992

Pockets

9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	423	0.78	0.87	63	empty
2	1044	0.74	0.77	101	empty
3	1009	0.73	0.77	98	empty
4	148	0.43	0.75	29	empty
5	133	0.40	0.75	27	empty

Interfaces

1 interface between chains.

A–B · 997 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

4RF6 · Crystal structure of double-domain arginine kinase from Anthopleura japonicas · the same entry in another collection · chain A against A, TM-score 1.00
O15992 · AlphaFold monomer V2.0 prediction for arginine kinase (O15992) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O15992
Elsewhere: RCSB PDB 4RF6 · PDBe 4RF6 · UniProt O15992

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