Research workbench
Crystal structure of double-domain arginine kinase from anthopleura japonicas
Analyse Crystal structure of double-domain arginine kinase from anthopleura japonicas in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4RF6
- Type
- protein
- Length
- 1,394 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Arginine kinase
- EC
- 2.7.3.3
- UniProt
- O15992
- Pockets
- 9 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Arginine kinase (EC 2.7.3.3) | protein | 696 | 41% helix, 17% strand | O15992 |
| B | Arginine kinase (EC 2.7.3.3) | protein | 698 | 40% helix, 17% strand | O15992 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 423 | 0.78 | 0.87 | 63 | empty |
| 2 | 1044 | 0.74 | 0.77 | 101 | empty |
| 3 | 1009 | 0.73 | 0.77 | 98 | empty |
| 4 | 148 | 0.43 | 0.75 | 29 | empty |
| 5 | 133 | 0.40 | 0.75 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 997 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 4RF6 · Crystal structure of double-domain arginine kinase from Anthopleura japonicas · the same entry in another collection · chain A against A, TM-score 1.00
- O15992 · AlphaFold monomer V2.0 prediction for arginine kinase (O15992) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15992
- Elsewhere: RCSB PDB 4RF6 · PDBe 4RF6 · UniProt O15992
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