MolNFT v1 · #105770 · protein
Crystal structure of the middle-east respiratory syndrome coronavirus papain-like protease
4REZ · ORF1AB protein: “Crystal structure of the middle-east respiratory syndrome coronavirus papain-like protease”. X-ray diffraction, 1 ligand (ZN), 2 pockets (best druggability 0.48). MolNFT v1 #105770 on GenesisL1: 3D structure…
- PDB
- 4REZ
- Type
- protein
- Length
- 311 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ORF1AB protein
- UniProt
- M4STU1
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.48
Structure
x-ray diffraction · 1 distinct chain · 25% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ORF1AB protein | protein | 311 | 25% helix, 38% strand | M4STU1 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 145 | 0.48 | 0.78 | 24 | PGO |
| 2 | 81 | 0.43 | 0.79 | 16 | PGO |
Compared structures
- 4REZ · Crystal structure of the Middle-East respiratory syndrome coronavirus papain-like protease · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt M4STU1
- Elsewhere: RCSB PDB 4REZ · PDBe 4REZ · UniProt M4STU1
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