MolNFT v1 · #10571 · protein

Crystal structure of rat hemeoxygenase-1 in complex with heme and azide.

1IVJ: “Crystal structure of rat hemeoxygenase-1 in complex with heme and azide.”. X-ray diffraction, 2 ligands (HEM, AZI), 1 pocket (best druggability 0.73). MolNFT v1 #10571 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1IVJ
Type: protein
Length: 212 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hemeoxygenase-1
EC: 1.14.99.3
UniProt: P06762
Ligands: HEM, AZI
Pockets: 1 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 75% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hemeoxygenase-1 (EC 1.14.99.3)	protein	212	75% helix, 0% strand	P06762

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · chains A
AZI · Azide ion · ion · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	308	0.73	0.85	36	AZI, HEM

Compared structures

1IVJ · Crystal Structure of Rat Hemeoxygenase-1 in Complex with Heme and Azide. · the same entry in another collection · chain A against A, TM-score 1.00
P06762 · AlphaFold monomer V2.0 prediction for heme oxygenase 1 (P06762) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06762
Elsewhere: RCSB PDB 1IVJ · PDBe 1IVJ · UniProt P06762

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