MolNFT v1 · #105580 · protein

Anti CD70 llama glama Fab 27B3

4R90 · Anti CD70 llama glama Fab 27B3 light chain: “Anti CD70 llama glama Fab 27B3”. X-ray diffraction, 1 ligand (CA), 3 pockets (best druggability 0.68). MolNFT v1 #105580 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4R90
Type: protein
Length: 434 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Anti CD70 llama glama Fab 27B3 light chain; Anti CD70 llama glama Fab 27B3 heavy chain
Ligands: CA
Pockets: 3 · best druggability 0.68

Structure

x-ray diffraction · 2 distinct chains · 9% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
L	Anti CD70 llama glama Fab 27B3 light chain	protein	210	8% helix, 51% strand	—
H	Anti CD70 llama glama Fab 27B3 heavy chain	protein	224	9% helix, 51% strand	—

Ligands and binding sites

CA · Calcium ion · metal · chains H
GOL · Glycerol · additive · chains L, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	851	0.68	0.75	79	GOL
2	136	0.43	0.76	29	empty
3	90	0.40	0.77	17	empty

Interfaces

1 interface between chains.

L–H · 1812 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

4R90 · Anti CD70 Llama glama Fab 27B3 · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4R90 · PDBe 4R90

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