MolNFT v1 · #105543 · protein
Crystal structure of an active mcm hexamer
4R7Y · Minichromosome maintenance protein mcm, cell division…: “Crystal structure of an active mcm hexamer”. X-ray diffraction, 4 ligands (ADP, MG, ZN), 15 pockets (best druggability 0.85). MolNFT v1 #105543 on GenesisL1: 3D structure…
- PDB
- 4R7Y
- Type
- protein
- Length
- 1,182 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Minichromosome maintenance protein mcm, cell division control protein 21
- EC
- 3.6.4.12
- UniProt
- Q9UXG1, Q8U3I4
- Ligands
- ADP, MG, ZN, CL
- Pockets
- 15 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Minichromosome maintenance protein mcm, cell division control protein 21 (EC 3.6.4.12) | protein | 591 | 37% helix, 23% strand | Q9UXG1, Q8U3I4 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 2 copies · chains A, B
- ZN · Zinc ion · metal · 2 copies · chains A, B
- CL · Chloride ion · ion · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1022 | 0.85 | 0.86 | 107 | ADP, MG |
| 2 | 476 | 0.71 | 0.81 | 66 | empty |
| 3 | 667 | 0.69 | 0.76 | 60 | empty |
| 4 | 335 | 0.56 | 0.76 | 40 | empty |
| 5 | 310 | 0.55 | 0.76 | 41 | empty |
Interfaces
1 interface between chains.
- A–B · 2691 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UXG1
- Every structure of UniProt Q8U3I4
- Elsewhere: RCSB PDB 4R7Y · PDBe 4R7Y · UniProt Q9UXG1 · UniProt Q8U3I4
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.