MolNFT v1 · #105309 · protein

Crystal structure of human CSN6 mpn domain

4R14 · COP9 signalosome complex subunit 6: “Crystal structure of human CSN6 mpn domain”. X-ray diffraction, 1 ligand (HG), 3 pockets (best druggability 0.75). MolNFT v1 #105309 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4R14
Type: protein
Length: 306 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: COP9 signalosome complex subunit 6
UniProt: Q7L5N1
Ligands: HG
Pockets: 3 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 27% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	COP9 signalosome complex subunit 6	protein	153	27% helix, 37% strand	Q7L5N1

Ligands and binding sites

HG · Mercury (II) ion · metal · 8 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	347	0.75	0.86	37	empty
2	361	0.64	0.79	36	HG
3	61	0.33	0.76	17	empty

Interfaces

1 interface between chains.

A–B · 765 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

4R14 · Crystal structure of human CSN6 MPN domain · the same entry in another collection · chain A against A, TM-score 1.00
Q7L5N1 · AlphaFold monomer V2.0 prediction for COP9 signalosome complex subunit 6 (Q7L5N1) · a predicted model of the same protein · chain B against A, TM-score 0.76

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7L5N1
Elsewhere: RCSB PDB 4R14 · PDBe 4R14 · UniProt Q7L5N1

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