UniProt Q7L5N1
COP9 signalosome complex subunit 6 (Q7L5N1)
COP9 signalosome complex subunit 6 (UniProt Q7L5N1): 20 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 121 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q7L5N1
- Protein
- COP9 signalosome complex subunit 6
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 121 · 18 records with a druggable one
Structures
21 records of Q7L5N1 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4D10 | Crystal structure of the COP9 signalosome | x-ray diffraction | F, N | — | 12 (best 0.78) |
| 4D10 | Crystal structure of the COP9 signalosome | x-ray diffraction | F, N | — | 12 (best 0.78) |
| 4D18 | Crystal structure of the COP9 signalosome | x-ray diffraction | F, N | — | 12 (best 0.77) |
| 4D18 | Crystal structure of the COP9 signalosome | x-ray diffraction | F, N | — | 12 (best 0.77) |
| 4QFT | Structure of COP9 signalosome complex subunit 6 | x-ray diffraction | A | — | — |
| 4QFT | Structure of COP9 signalosome complex subunit 6 | x-ray diffraction | A | — | — |
| 4R14 | Crystal structure of human CSN6 MPN domain | x-ray diffraction | A, B | HG | 3 (best 0.75) |
| 4R14 | Crystal structure of human CSN6 mpn domain | x-ray diffraction | A, B | HG | 3 (best 0.75) |
| 4WSN | Crystal structure of the COP9 signalosome, a P1 crystal form | x-ray diffraction | F, N, V, d, l, t | — | 18 (best 0.78) |
| 6R6H | Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome | electron microscopy | F | — | 3 (best 0.81) |
| 6R6H | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | F | — | 3 (best 0.81) |
| 6R7F | Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome | electron microscopy | F | — | 5 (best 0.81) |
| 6R7F | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | F | — | 5 (best 0.81) |
| 6R7H | Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome | electron microscopy | F | — | 4 (best 0.86) |
| 6R7H | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | F | — | 4 (best 0.86) |
| 6R7I | Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome | electron microscopy | F | — | 3 (best 0.87) |
| 6R7I | Structural basis of cullin-2 ring E3 ligase regulation by the COP9 signalosome | electron microscopy | F | — | 3 (best 0.87) |
| 8H38 | Cryo-EM Structure of the KBTBD2-CRL3~N8-CSN(mutate) complex | electron microscopy | F | — | 7 (best 0.86) |
| 8H3A | Cryo-EM Structure of the KBTBD2-CRL3~N8(removed)-CSN complex | electron microscopy | F | — | 6 (best 0.85) |
| 8H3F | Cryo-EM Structure of the KBTBD2-CRL3-CSN complex | electron microscopy | F | — | 5 (best 0.83) |
| Q7L5N1 | AlphaFold monomer V2.0 prediction for COP9 signalosome complex subunit 6 (Q7L5N1) | predicted | A | — | 1 (best 0.30) |
Ligands
- HG · Mercury (II) ion · in 2 records
Experiment against prediction
- 4QFT chain A against the predicted model Q7L5N1: TM-score 0.95, RMSD 1.38 Å
- 4QFT chain A against the predicted model Q7L5N1: TM-score 0.95, RMSD 1.38 Å
- 4D18 chain F against the predicted model Q7L5N1: TM-score 0.78, RMSD 3.35 Å
- 4D18 chain F against the predicted model Q7L5N1: TM-score 0.78, RMSD 3.35 Å
- 4D18 chain N against the predicted model Q7L5N1: TM-score 0.78, RMSD 3.38 Å
- 4D18 chain N against the predicted model Q7L5N1: TM-score 0.78, RMSD 3.38 Å
- 4D10 chain F against the predicted model Q7L5N1: TM-score 0.77, RMSD 3.65 Å
- 4D10 chain F against the predicted model Q7L5N1: TM-score 0.77, RMSD 3.65 Å
- 4WSN chain l against the predicted model Q7L5N1: TM-score 0.77, RMSD 3.46 Å
- 4WSN chain t against the predicted model Q7L5N1: TM-score 0.77, RMSD 3.48 Å
Elsewhere
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