MolNFT v1 · #105239 · protein
TRPB2 enzymes
4QYS · Tryptophan synthase beta chain 2: “TRPB2 enzymes”. X-ray diffraction, 3 ligands (PLR, PLP, SEP), 6 pockets (best druggability 0.83). MolNFT v1 #105239 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4QYS
- Type
- protein
- Length
- 826 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tryptophan synthase beta chain 2
- EC
- 4.2.1.20
- UniProt
- Q97TX6
- Ligands
- PLR, PLP, SEP
- Pockets
- 6 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Tryptophan synthase beta chain 2 (EC 4.2.1.20) | protein | 418 | 44% helix, 18% strand | Q97TX6 |
| A | Tryptophan synthase beta chain 2 (EC 4.2.1.20) | protein | 408 | 42% helix, 19% strand | Q97TX6 |
Ligands and binding sites
- PLR · (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate · ligand · chains B
- PLP · Pyridoxal-5'-phosphate · ligand · chains A
- SEP · Phosphoserine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 524 | 0.83 | 0.89 | 83 | PLP, SEP |
| 2 | 672 | 0.80 | 0.85 | 71 | PLR |
| 3 | 101 | 0.78 | 0.98 | 25 | empty |
| 4 | 118 | 0.59 | 0.84 | 21 | empty |
| 5 | 53 | 0.32 | 0.77 | 13 | empty |
Interfaces
1 interface between chains.
- B–A · 2252 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q97TX6
- Elsewhere: RCSB PDB 4QYS · PDBe 4QYS · UniProt Q97TX6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.