MolNFT v1 · #105079 · protein
The structure of JMJD7 with alpha-kg
4QU2 · Jmjc domain-containing protein 7: “The structure of JMJD7 with alpha-kg”. X-ray diffraction, 2 ligands (AKG, NI), 3 pockets (best druggability 0.67). MolNFT v1 #105079 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4QU2
- Type
- protein
- Length
- 636 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Jmjc domain-containing protein 7
- UniProt
- P0C872
- Ligands
- AKG, NI
- Pockets
- 3 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Jmjc domain-containing protein 7 | protein | 318 | 31% helix, 31% strand | P0C872 |
Ligands and binding sites
- AKG · 2-oxoglutaric acid · ligand · 2 copies · chains A, B
- NI · Nickel (II) ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.67 | 0.96 | 20 | empty |
| 2 | 225 | 0.62 | 0.81 | 43 | NI, AKG |
| 3 | 232 | 0.56 | 0.78 | 45 | AKG |
Interfaces
1 interface between chains.
- A–B · 1807 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C872
- Elsewhere: RCSB PDB 4QU2 · PDBe 4QU2 · UniProt P0C872
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