MolNFT v1 · #105042 · protein

SHP2 SH2 domain in complex with GAB1 peptide

4QSY · Tyrosine-protein phosphatase non-receptor type 11: “SHP2 SH2 domain in complex with GAB1 peptide”. X-ray diffraction. MolNFT v1 #105042 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4QSY
Type: protein
Length: 111 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosine-protein phosphatase non-receptor type 11; GRB2-associated-binding protein 1
EC: 3.1.3.48
UniProt: Q06124, Q13480

Structure

x-ray diffraction · 2 distinct chains · 19% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48)	protein	100	21% helix, 31% strand	Q06124
B	GRB2-associated-binding protein 1	protein	11	0% helix, 18% strand	Q13480

Interfaces

1 interface between chains.

A–B · 686 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

4QSY · SHP2 SH2 domain in complex with GAB1 peptide · the same entry in another collection · chain B against B, TM-score 1.00
Q13480 · AlphaFold monomer V2.0 prediction for GRB2-associated-binding protein 1 (Q13480) · a predicted model of the same protein · chain B against A, TM-score 0.36

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q06124
Every structure of UniProt Q13480
Elsewhere: RCSB PDB 4QSY · PDBe 4QSY · UniProt Q06124 · UniProt Q13480

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