MolNFT v1 · #104680 · protein
The structure of AIF2GAMMA subunit H20F/D152A from archaeon sulfolobus solfataricus complexed with gdpcp
4QHY · Translation initiation factor 2 subunit gamma: “The structure of AIF2GAMMA subunit H20F/D152A from archaeon sulfolobus solfataricus complexed with gdpcp”. X-ray diffraction, 2 ligands (GCP, MG), 5 pockets (best druggability 0.62).…
- PDB
- 4QHY
- Type
- protein
- Length
- 414 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Translation initiation factor 2 subunit gamma
- UniProt
- Q980A5
- Ligands
- GCP, MG
- Pockets
- 5 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 17% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Translation initiation factor 2 subunit gamma | protein | 414 | 17% helix, 39% strand | Q980A5 |
Ligands and binding sites
- GCP · Phosphomethylphosphonic acid guanylate ester · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 386 | 0.62 | 0.78 | 57 | empty |
| 2 | 302 | 0.57 | 0.77 | 40 | empty |
| 3 | 83 | 0.44 | 0.80 | 19 | MG, GCP |
| 4 | 93 | 0.33 | 0.73 | 20 | empty |
| 5 | 53 | 0.29 | 0.75 | 12 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4QHY · The structure of aIF2gamma subunit H20F/D152A from archaeon Sulfolobus solfataricus… · the same entry in another collection · chain A against A, TM-score 1.00
- Q980A5 · AlphaFold monomer V2.0 prediction for translation initiation factor 2 subunit gamma… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q980A5
- Elsewhere: RCSB PDB 4QHY · PDBe 4QHY · UniProt Q980A5
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