MolNFT v1 · #104654 · protein

LC8 - ANA2 (159-168) complex

4QH7 · Dynein light chain 1, cytoplasmic: “LC8 - ANA2 (159-168) complex”. X-ray diffraction, 2 pockets (best druggability 0.42). MolNFT v1 #104654 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4QH7
Type: protein
Length: 376 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dynein light chain 1, cytoplasmic; Anastral spindle 2
UniProt: Q24117, Q9XZ31
Pockets: 2 · best druggability 0.42

Structure

x-ray diffraction · 5 distinct chains · 26% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, E, F	Dynein light chain 1, cytoplasmic	protein	83	40% helix, 45% strand	Q24117
C	Anastral spindle 2	protein	12	0% helix, 58% strand	Q9XZ31
D	Anastral spindle 2	protein	10	0% helix, 70% strand	Q9XZ31
G	Anastral spindle 2	protein	11	0% helix, 64% strand	Q9XZ31
H	Anastral spindle 2	protein	11	0% helix, 64% strand	Q9XZ31

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	156	0.42	0.74	25	empty
2	125	0.36	0.72	18	empty

Interfaces

11 interfaces between chains.

A–B · 914 Å² buried · 23 hydrogen bonds · protein-protein
E–F · 901 Å² buried · 22 hydrogen bonds · protein-protein
E–G · 674 Å² buried · 21 hydrogen bonds · protein-protein
A–C · 657 Å² buried · 20 hydrogen bonds · protein-protein
F–H · 649 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

4QH7 · LC8 - Ana2 (159-168) Complex · the same entry in another collection · chain H against H, TM-score 1.00
Q24117 · AlphaFold monomer V2.0 prediction for dynein light chain 1, cytoplasmic (Q24117) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q24117
Every structure of UniProt Q9XZ31
Elsewhere: RCSB PDB 4QH7 · PDBe 4QH7 · UniProt Q24117 · UniProt Q9XZ31

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