MolNFT v1 · #104581 · protein

Crystal structure of human BAZ2A phd zinc finger in the free form

4QF2 · Bromodomain adjacent to zinc finger domain protein 2A: “Crystal structure of human BAZ2A phd zinc finger in the free form”. X-ray diffraction, 2 ligands (ZN, PO4), 2 pockets (best druggability 0.51). MolNFT v1 #104581 on GenesisL1…

PDB: 4QF2
Type: protein
Length: 209 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bromodomain adjacent to zinc finger domain protein 2A
UniProt: Q9UIF9
Ligands: ZN, PO4
Pockets: 2 · best druggability 0.51

Structure

x-ray diffraction · 3 distinct chains · 17% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, D	Bromodomain adjacent to zinc finger domain protein 2A	protein	53	13% helix, 15% strand	Q9UIF9
B	Bromodomain adjacent to zinc finger domain protein 2A	protein	51	22% helix, 16% strand	Q9UIF9
C	Bromodomain adjacent to zinc finger domain protein 2A	protein	52	17% helix, 15% strand	Q9UIF9

Ligands and binding sites

ZN · Zinc ion · metal · 8 copies · chains A, B, C, D
PO4 · Phosphate ion · ion · 3 copies · chains A, B, D
GOL · Glycerol · additive · chains C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	81	0.51	0.84	17	empty
2	61	0.47	0.84	15	empty

Interfaces

6 interfaces between chains.

A–C · 732 Å² buried · 12 hydrogen bonds · protein-protein
B–D · 684 Å² buried · 8 hydrogen bonds · protein-protein
A–D · 421 Å² buried · 6 hydrogen bonds · protein-protein
A–B · 85 Å² buried · 0 hydrogen bonds · protein-protein
C–D · 79 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

4QF2 · Crystal structure of human BAZ2A PHD zinc finger in the free form · the same entry in another collection · chain D against D, TM-score 1.00
Q9UIF9 · AlphaFold monomer V2.0 prediction for bromodomain adjacent to zinc finger domain protein… · a predicted model of the same protein · chain C against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UIF9
Elsewhere: RCSB PDB 4QF2 · PDBe 4QF2 · UniProt Q9UIF9

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