MolNFT v1 · #104473 · protein
The second sphere residue T263 is important for function and activity of PTP1B through modulating wpd loop
4QBE · Tyrosine-protein phosphatase non-receptor type 1: “The second sphere residue T263 is important for function and activity of PTP1B through modulating wpd loop”. X-ray diffraction, 2 pockets (best druggability 0.43). MolNFT v1 #104473…
- PDB
- 4QBE
- Type
- protein
- Length
- 298 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 1
- EC
- 3.1.3.48
- UniProt
- P18031
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) | protein | 298 | 34% helix, 21% strand | P18031 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 118 | 0.43 | 0.77 | 21 | empty |
| 2 | 54 | 0.29 | 0.75 | 13 | empty |
Compared structures
- 4QBE · The second sphere residue T263 is important for function and activity of PTP1B through… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18031
- Elsewhere: RCSB PDB 4QBE · PDBe 4QBE · UniProt P18031
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