MolNFT v1 · #104376 · protein
TRNA-guanine transglycosylase (tgt) mutant V262C apo structure
4Q8N · Queuine tRNA-ribosyltransferase: “TRNA-guanine transglycosylase (tgt) mutant V262C apo structure”. X-ray diffraction, 1 ligand (ZN), 2 pockets (best druggability 0.68). MolNFT v1 #104376 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4Q8N
- Type
- protein
- Length
- 366 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Queuine tRNA-ribosyltransferase
- EC
- 2.4.2.29
- UniProt
- P28720
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Queuine tRNA-ribosyltransferase (EC 2.4.2.29) | protein | 366 | 45% helix, 19% strand | P28720 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 260 | 0.68 | 0.84 | 43 | GOL |
| 2 | 170 | 0.53 | 0.79 | 23 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4Q8N · tRNA-Guanine Transglycosylase (TGT) Mutant V262C Apo Structure · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28720
- Elsewhere: RCSB PDB 4Q8N · PDBe 4Q8N · UniProt P28720
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