MolNFT v1 · #104239 · protein

TM287/288 in its apo state

4Q4H · ABC transporter: “TM287/288 in its apo state”. X-ray diffraction, 15 pockets (best druggability 0.82). MolNFT v1 #104239 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4Q4H
Type: protein
Length: 1,155 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ABC transporter; Uncharacterized ABC transporter ATP-binding protein TM_0288
UniProt: Q9WYC3, Q9WYC4
Pockets: 15 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 63% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ABC transporter	protein	572	63% helix, 11% strand	Q9WYC3
B	Uncharacterized ABC transporter ATP-binding protein TM_0288	protein	583	62% helix, 9% strand	Q9WYC4

Pockets

15 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	992	0.82	0.83	86	empty
2	632	0.77	0.83	91	empty
3	187	0.69	0.86	26	empty
4	167	0.54	0.79	22	empty
5	267	0.54	0.76	29	empty

Interfaces

1 interface between chains.

A–B · 6602 Å² buried · 43 hydrogen bonds · protein-protein

Compared structures

4Q4H · TM287/288 in its apo state · the same entry in another collection · chain A against A, TM-score 1.00
Q9WYC4 · AlphaFold monomer V2.0 prediction for uncharacterized ABC transporter ATP-binding protein… · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9WYC3
Every structure of UniProt Q9WYC4
Elsewhere: RCSB PDB 4Q4H · PDBe 4Q4H · UniProt Q9WYC3 · UniProt Q9WYC4

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.