MolNFT v1 · #103994 · protein

The crystal structure of atuah in complex with glyoxylate

4PXE · Ureidoglycolate hydrolase: “The crystal structure of atuah in complex with glyoxylate”. X-ray diffraction, 2 ligands (GLV, MN), 5 pockets (best druggability 0.58). MolNFT v1 #103994 on GenesisL1: 3D structure, binding sites and…

PDB: 4PXE
Type: protein
Length: 846 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ureidoglycolate hydrolase
EC: 3.5.3.19
UniProt: Q8VXY9
Ligands: GLV, MN
Pockets: 5 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Ureidoglycolate hydrolase (EC 3.5.3.19)	protein	423	38% helix, 25% strand	Q8VXY9

Ligands and binding sites

GLV · Glyoxylic acid · ligand · 2 copies · chains A, B
MN · Manganese (II) ion · metal · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	366	0.58	0.76	58	empty
2	175	0.54	0.79	36	empty
3	163	0.54	0.80	29	empty
4	232	0.52	0.76	44	empty
5	55	0.40	0.81	16	empty

Interfaces

1 interface between chains.

A–B · 2503 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

4PXE · The crystal structure of AtUAH in complex with glyoxylate · the same entry in another collection · chain A against A, TM-score 1.00
Q8VXY9 · AlphaFold monomer V2.0 prediction for ureidoglycolate hydrolase (Q8VXY9) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8VXY9
Elsewhere: RCSB PDB 4PXE · PDBe 4PXE · UniProt Q8VXY9

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.