MolNFT v1 · #10387 · protein
Crystal structure of the importin-ALPHA(44-54)-importin- ALPHA(70-529) complex
1IQ1 · Importin alpha-2 subunit: “Crystal structure of the importin-ALPHA(44-54)-importin- ALPHA(70-529) complex”. X-ray diffraction, 2 pockets (best druggability 0.44). MolNFT v1 #10387 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1IQ1
- Type
- protein
- Length
- 442 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin alpha-2 subunit
- UniProt
- P52293
- Pockets
- 2 · best druggability 0.44
Structure
x-ray diffraction · 3 distinct chains · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin alpha-2 subunit | protein | 7 | 0% helix, 0% strand | P52293 |
| B | Importin alpha-2 subunit | protein | 9 | 0% helix, 0% strand | P52293 |
| C | Importin alpha-2 subunit | protein | 426 | 74% helix, 0% strand | P52293 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 66 | 0.44 | 0.81 | 12 | empty |
| 2 | 77 | 0.36 | 0.77 | 19 | empty |
Interfaces
2 interfaces between chains.
- B–C · 788 Ų buried · 22 hydrogen bonds · protein-protein
- A–C · 575 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 1IQ1 · Crystal structure of the importin-ALPHA(44-54)-importin-ALPHA(70-529) complex · the same entry in another collection · chain A against A, TM-score 1.00
- P52293 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52293) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Elsewhere: RCSB PDB 1IQ1 · PDBe 1IQ1 · UniProt P52293
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