MolNFT v1 · #103715 · protein

Vhh-metal in complex with RNase a

4POU · Ribonuclease pancreatic: “Vhh-metal in complex with RNase a”. X-ray diffraction, 1 pocket (best druggability 0.31). MolNFT v1 #103715 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4POU
Type: protein
Length: 240 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ribonuclease pancreatic; Vhh antibody
EC: 3.1.27.5
UniProt: P61823
Pockets: 1 · best druggability 0.31

Structure

x-ray diffraction · 2 distinct chains · 15% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ribonuclease pancreatic (EC 3.1.27.5)	protein	120	22% helix, 37% strand	P61823
B	Vhh antibody	protein	120	8% helix, 47% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	63	0.31	0.75	17	empty

Interfaces

1 interface between chains.

A–B · 687 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 disulfide (disulfide).

Compared structures

4POU · VHH-metal in Complex with RNase A · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P61823
Elsewhere: RCSB PDB 4POU · PDBe 4POU · UniProt P61823

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