MolNFT v1 · #103616 · protein
Crystal structure of plasmodium falciparum lactate dehydrogenase mutant W107FA.
4PLZ · L-lactate dehydrogenase: “Crystal structure of plasmodium falciparum lactate dehydrogenase mutant W107FA.”. X-ray diffraction, 2 ligands (OXM, NAI), 2 pockets (best druggability 0.61). MolNFT v1 #103616 on GenesisL1: 3D structure…
- PDB
- 4PLZ
- Type
- protein
- Length
- 302 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- L-lactate dehydrogenase
- EC
- 1.1.1.27
- UniProt
- Q71T02
- Ligands
- OXM, NAI
- Pockets
- 2 · best druggability 0.61
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | L-lactate dehydrogenase (EC 1.1.1.27) | protein | 302 | 50% helix, 21% strand | Q71T02 |
Ligands and binding sites
- OXM · Oxamic acid · ligand · chains A
- NAI · 1,4-dihydronicotinamide adenine dinucleotide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 415 | 0.61 | 0.76 | 56 | OXM, NAI |
| 2 | 125 | 0.44 | 0.77 | 22 | empty |
Compared structures
- 4PLZ · Crystal structure of Plasmodium falciparum lactate dehydrogenase mutant W107fA. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q71T02
- Elsewhere: RCSB PDB 4PLZ · PDBe 4PLZ · UniProt Q71T02
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